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Molecules and compositions are described for use in the treatment and prevention of pro-inflammatory conditions. In one embodiment, the contacting occurs prior to exposure to oxidative stress.
HDL-related molecules, including Apo A-I, bovine HDL and HDL mimetics, in particular, are demonstrated to prevent UV-induced cell death and oxidative stress in skin cells and to inhibit tumor growth and development in a variety of cancers. provisional patent application 61/646,772, filed May 14, 2012, 61/624,333, filed Apr. 29, 2011, the entire contents of each of which are incorporated herein by reference. In a typical embodiment, the contacting occurs at least 12-24 hours prior to the exposure to oxidative stress.
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7,670,792, which is a national stage filing under 35 U. Proinflammatory activities in general are initiated to overcome infection or invasion of potentially deleterious biological agents (bacteria, viruses, parasites etc.).
In one embodiment, the Apo A-I is natural, full-length, unmodified Apo A-I.
The method of any one of claims 1-6, wherein the HDL mimetic peptide is selected from the group consisting of SEQ ID NO: 1, 3-9, 12, 14 and 26-28.
HDL-related molecules can be used as an oral supplement and in other compositions to prevent or treat pro-inflammatory skin conditions and systemic proinflammatory conditions, including Alzheimer's disease and various cancers. The oxidative stress may comprise, for example, exposure to ultraviolet radiation.
The method comprises contacting the epithelial cells with an HDL-related molecule selected from the group consisting of HDL mimetic peptides (such as those shown in SEQ ID NO: 1, 3-9, 12, 14 or 26-28), bovine HDL, and Apo A-I.
14, 2004, the entire contents of each of which are incorporated herein by reference.